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. Author manuscript; available in PMC: 2022 Mar 30.
Published in final edited form as: Immunol Rev. 2021 Jul 26;303(1):52–61. doi: 10.1111/imr.12992

Figure 2. Stepwise UPR implementation across B cell differentiation.

Figure 2.

This schematic illustrates the distinct segments of gene expression changes that occur in the earliest phases of plasma cell differentiation. Initiation marks the start of stimulus and the rapid induction of genes required for building the translation machinery, which is followed by the more gradual onset of genes required for building the secretory apparatus. Indicated are the relative times to full Blimp1 induction and Xbp1 splicing for both follicular and MZ B cells. Note that basal expression of these genes occurs along with basal mTORC1 activity in MZ B cells yielding faster differentiation kinetics.