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. 2022 Mar 29;6(4):e705. doi: 10.1097/HS9.0000000000000705

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Morphological features of the composite lymphomas identified in lymph node and tongue biopsies (A) H&E–stained whole slide image of the cervical lymph node biopsy (maximum tissue dimension = 1.8 cm). (B) Lymph node area showing cHL, OM ×40, H&E, inset: high-power view of a representative HRS cell OM ×100 oil immersion. (C) cHL, OM ×20, CD30 highlighting HRS cells. (D) Lymph node area showing DLBCL, OM ×40, H&E. (E) DLBCL, OM ×20, CD20. (F) H&E-stained whole slide image of the tongue mass biopsy (image width = 1.1 cm). (G) Tongue mass area showing DLBCL, OM ×40, H&E. (H) DLBCL, OM ×10, CD20. (I) Tongue mass area showing FOLL3B, OM ×10, H&E. (J) FOLL3B, OM ×10, CD21 highlighting follicular dendritic cell meshwork. cHL = classic Hodgkin lymphoma; DLBCL = diffuse large B-cell lymphomas; FOLL3B = follicular lymphoma grade 3B; H&E = hematoxylin and eosin; HRS = Hodgkin Reed-Sternberg; OM = objective magnification.