TABLE 5.
Clinical course and complications in patients with moderate and severe COVID-19
| Moderate (n = 18) | Severe (n = 13) | P | |
|---|---|---|---|
| Died, n (%) | 1 (6) | 7 (54) | <0.001 |
| Required mechanical ventilation, n (%) | – | 7 (54) | – |
| Days on ventilator | – | Median, 11 (IQR, 3–33)Mean, 22.9 (range, 3–74) | – |
| Received ECMO support, n (%) | 0 (0) | 0 (0) | – |
| Total LOS (d), median (IQR) | 9 (5–15) | 28 (10–57) | 0.025 |
| Combined ICU/SDU LOS (d) | – | Median, 13 (IQR, 10–36)Mean, 29 (range, 0–106) | – |
| Complications, n | |||
| AKI | 10 (63)a | 11 (85)a | 0.083 |
| New arrhythmia | 2 (13) | 2 (15) | 0.74 |
| VTE/arterial thrombi | 0 (0) | 4 (31) | 0.011 |
| Transaminitis | 6 (38) | 10 (77) | 0.023 |
| Neurological events | 1 (6) | 7 (54) | 0.006 |
| Coinfection | 5 (31) | 9 (69) | 0.031 |
| Respiratoryb | 2 (13) | 5 (38) | 0.092 |
| BSIc | 2 (13) | 2 (15) | 0.78 |
| CMV | 1 (6) | 3 (23) | 0.18 |
| Otherd | 2 (13) | 3 (23) | 0.43 |
aOne patient was already on hemodialysis at baseline and is not included in this total.
bRespiratory infections included rhinovirus, enterovirus, Aspergillus fumigatus, Pseudomonas aeruginosa, Stenotrophomonas, Klebsiella, E coli, and methicillin-resistant Staphylococcus aureus.
cBlood stream infections included Staphylococcus epidermidis, vancomycin-resistant Enterococcus.
dOther coinfections included Epstein-Barr virus; gastrointestinal cultures positive for Clostridium difficile, Yersinia; and urine cultures positive for Pseudomonas aeruginosa, BK virus, and Citrobacter.
AKI, acute kidney injury; BSI, blood stream infection; CMV, cytomegalovirus; COVID-19, coronavirus disease 2019; ECMO, extracorporeal membrane oxygenator; E coli, Escherichia coli; ICU, intensive care unit; IQR, interquartile range; LOS, length of stay; SDU, step down unit; VTE, venous thromboembolism.