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. 2022 Mar 28;23(1):310–318. doi: 10.1080/15384047.2022.2055420

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Patient derived HNSCC cells were exposed to trametinib at a max concentration of 20 μM. (a) Differential AUCs of HNSCC cohort of 20 tumors. Highlighted selected cases: Sensitive cases (blue bars), resistant cases (red bars), HNSCC cells (black bars), and tumor matched normal tissues 10309 and 20004 (gray bars). Red line demarcates no drug effect. (b) At time of selection, sensitive cases that were <20% of the median IC50 values where selected for validation. Selected cases were validated in an extended dose response assay for 2 sensitive and 3 resistant cell lines.