Table 1.
Top 10 most strongly associated loci with migraine and each of depression (depression) and schizophrenia (schizophrenia)
| Chr | Min-max base pairs | Lead SNPs | ConjFDR | Psych | Migraine | Overlapping | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Effect size (OR) | P-value | Novel | Effect size (Beta) | P-value | Novel | |||||
| Migraine and depression | ||||||||||
| 1 | 73 458 846–74 108 971 | rs11210247 | <0.001 | 1.06 | 6.62 × 10−9 | No | −0.04 | 1.69 × 10−7 | No | Yes |
| 2 | 208 017 033–208 088 987 | rs7592120 | 0.03 | 0.94 | 4.46 × 10−8 | No | −0.03 | 4.78 × 10−5 | Yes | Yes |
| 5 | 92 362 700–92 538 853 | rs10514370 | 0.02 | 0.96 | 9.39 × 10−6 | Yes | −0.03 | 2.95 × 10−5 | Yes | No |
| 8 | 64 496 159–64 624 581 | rs1217091 | 0.03 | 0.95 | 1.23 × 10−5 | Yes | 0.04 | 3.93 × 10−5 | Yes | Yes |
| 8 | 131 030 628–131 361 477 | rs143725649 | 0.03 | 1.04 | 5.85 × 10−5 | Yes | −0.04 | 6.08 × 10−5 | Yes | No |
| 9 | 23 736 400–23 737 627 | rs10119773 | 0.03 | 0.95 | 7.70 × 10−8 | No | −0.03 | 5.02 × 10−5 | Yes | No |
| 9 | 37 045 825–37 406 391 | rs10973193 | 0.03 | 1.08 | 4.96 × 10−8 | No | 0.04 | 3.85 × 10−5 | Yes | No |
| 9 | 98 191 712–98 314 415 | rs10512249 | 0.02 | 1.07 | 3.28 × 10−5 | No | 0.05 | 1.48 × 10−5 | Yes | No |
| 15 | 47 615 220–47 685 504 | rs281264 | 0.03 | 0.96 | 2.25 × 10−5 | No | −0.03 | 4.26 × 10−5 | Yes | No |
| 22 | 41 408 754–41 713 111 | rs71327107 | 0.01 | 0.95 | 4.02 × 10−6 | No | −0.04 | 1.45 × 10−5 | Yes | Yes |
| Migraine and schizophrenia | ||||||||||
| 1 | 73 305 593–74 161 292 | rs11210247 | <0.001 | 1.07 | 1.92 × 10−11 | No | −0.04 | 1.69 × 10−7 | No | Yes |
| 1 | 115 677 183–115 763 649 | rs12134493 | 0.002 | 1.08 | 6.29 × 10−7 | Yes | 0.11 | 1.01 × 10−22 | No | No |
| 3 | 16 947 451–16 972 211 | rs11128810 | 0.008 | 1.04 | 8.66 × 10−6 | No | −0.04 | 3.39 × 10−6 | No | No |
| 4 | 103 618 023–103 975 060 | rs6810668 | 0.008 | 1.04 | 8.04 × 10−6 | No | −0.03 | 1.04 × 10−5 | Yes | No |
| 8 | 64 496 159–64 842 662 | rs1217112 | 0.004 | 1.06 | 2.94 × 10−6 | No | −0.04 | 4.60 × 10−6 | Yes | Yes |
| 11 | 46 257 757–47 371 598 | rs7932866 | <0.001 | 0.92 | 1.06 × 10−10 | No | 0.05 | 6.36 × 10−7 | Yes | No |
| 12 | 57 331 741–57 527 283 | rs324015 | <0.001 | 0.93 | 1.42 × 10−10 | No | 0.05 | 1.26 × 10−8 | No | No |
| 16 | 4 447 771–4 596 447 | rs4786505 | 0.001 | 0.95 | 2.85 × 10−7 | No | −0.04 | 1.07 × 10−6 | Yes | No |
| 17 | 78 442 650–78 738 796 | rs112821038 | 0.006 | 0.93 | 5.51 × 10−6 | No | 0.06 | 4.76 × 10−6 | No | No |
| 22 | 41 408 754–41 713 111 | rs71327107 | 0.009 | 0.93 | 3.71 × 10−10 | No | −0.04 | 1.45 × 10−5 | Yes | Yes |
For the complete list of loci please refer to Supplementary Tables 2 and 3. Chromosome (Chr), minimum and maximum base pairs, lead SNPs and conjFDR statistic are presented from each conjFDR analysis. Effect sizes [either odds ratio (OR) for depression and schizophrenia or beta for migraine] and P-values are presented from the original mental disorder (psych) and migraine GWAS. The novelty of each locus for migraine, depression and schizophrenia in relation to previous GWAS and conjFDR studies is indicated by Yes (novel) or No (not novel). ‘Overlapping’ indicates loci that were physically overlapping across both migraine and depression, and migraine and schizophrenia analyses.