Figure 3.

Decision-tree for the classification of MCI and MBI in pre-symptomatic ALS. An approach to determining the presence of MCI and MBI, based on the results of formal neuropsychological testing and an interview with a reliable informant. This decision-tree emphasizes the need to document changes in cognition and behaviour, and incorporates a hierarchical approach to weighing data from different sources. These guidelines also distinguish mild impairment from instances in which there is uncertainty about cognitive or behavioural impairment.