Extended Data Fig. 1 ∣. Ideal intermittent containment between N_min and N_max.

Times to progression are shown for ideal intermittent containment between N_min and N₀ for varied N_min value (solid curve), compared to ideal containment at either N₀ (dashed curve) or N_min (dotted curve), according to a Gompertzian growth model (Model 3 in the main text). Non-varied parameter values are as in main text Table 2. The kinks in the curve for ideal intermittent containment are due to the discontinuity of the treatment when a new cycle is completed, or in mathematical terms, to the integer part that appears in the explicit formula.