. Author manuscript; available in PMC: 2022 Mar 30.

Published in final edited form as: Nat Ecol Evol. 2021 Apr 12;5(6):826–835. doi: 10.1038/s41559-021-01428-w

Table 1 ∣.

Time to progression, treatment failure and survival time for Model 3

Treatment	t _prog	t _fail	t _surv
No treatment	0	77	226
Ideal MTD	186	263	412
MTD (C_max = 2)	236	314	463
C = 1.09	303	397	549
Containment at N₀ (C_max = 2)	318	418	568
Ideal containment at N₀	340	417	566
C = 1.07 from N = N_tol	0	543	731
Containment at N_tol (C_max = 2)	0	580	767
Ideal containment at N_tol	0	615	764
Intermittent containment (C_max = 2) between 0.5 N₀ and N₀	317	398	547
Intermittent containment (C_max = 2) between 0.8N₀ and N₀	325	411	561
Ideal intermittent containment between 0.5 N₀ and N₀	320	397	546
Ideal intermittent containment between 0.8N₀ and N₀	333	410	559

The constant dose or delayed constant doses C = 1.09 and C = 1.07 maximize t_prog and t_fail, respectively, among all constant dose or delayed constant dose treatments. Times are measured in days. Note that intermittent containment between N₀ and N_min=0.8N₀ leads to a larger time to progression than containment at N₀, but to a lower time to treatment failure and survival time. This is discussed in the Supplementary Information, section 4.3.