Table 2.
Descriptions of reliability scores8
| Reliability Score | Klimish Score | Description | Summary |
|---|---|---|---|
| RS1 | 1 | Data reliable without restriction | Well documented and accepted study or data from the literature |
| Performed according to valid and/or accepted test guidelines (e.g., OECD) | |||
| Preferably performed according to good laboratory practices (GLP) | |||
| RS2 | 2 | Data with restriction | Well documented and sufficient |
| Primarily not performed according to GLP | |||
| Partially complies with test guideline | |||
| RS3 | - | Exert review | Read-across |
| Expert review of in silico result(s) and/or Klimisch 3 or 4 data | |||
| RS4 | - | Multiple concurring prediction results | |
| RS5 | - | Single acceptable in silico result | |
| RS5 | 3 | Data not reliable | Inferences between the measuring system and test substance |
| Test system not relevant to exposure | |||
| Method not acceptable for the endpoint | |||
| RS5 | 4 | Data no assignable | Not sufficiently documented for an expert review |
| Lack of experimental details | |||
| Referenced from short abstract or secondary literature |