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. 2022 Mar 14;13:792660. doi: 10.3389/fphys.2022.792660

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Copyright © 2022 He, Fu, Zhao, Ren, Liu, Chen, Li, Zhou, Tang, Liu, Ye, Liu, Ma, Zhang, Ma, Zhang, Zhang, Li and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival probability predicted by typical CPET variables. Crude Kaplan-Meier curves during follow-up for (A) overall exercise capacity, represented by the VO₂ peak, (B) cardiovascular function, represented by HR peak, (C) pulmonary function, represented by VE/VCO₂ slope, and (D) breathing economy, represented by the VE/VO₂ peak. The cutoff value for the VO₂ peak was defined by previous studies. The cutoff values for the remaining three variables were based on the medians of patients in this study. |, censored patients. ALS, amyotrophic lateral sclerosis; CPET, cardiopulmonary exercise testing; VO₂, oxygen consumption; HR, heart rate; VE, minute ventilation; VCO₂, carbon dioxide production.