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. 2022 Mar 14;13:792660. doi: 10.3389/fphys.2022.792660

TABLE 3.

Correlations of CPET variables with disease characteristics of ALS.

Overall exercise capacity
VO2 peak
 Cardiovascular function
HR peak
 Pulmonary function
VE/VCO2 slope
 Breathing economy
VE/VO2 peak
R p R p R p R p
BMI −0.042 0.498 −0.198 0.039 −0.046 0.638 −0.301 0.002
FVC   0.383 <0.001   0.212 0.043   0.204 0.056   0.165 0.118
ALSFRS-R   0.475 <0.001   0.405 <0.001 −0.233 0.017 −0.063 0.517
UMN −0.122 0.207 −0.062 0.520 0.148 0.131   0.031 0.751
LMN −0.229 0.016 −0.087 0.368 0.325 0.001   0.199 0.039
KCSS −0.390 <0.001 −0.325 0.001 0.077 0.434   0.028 0.770
NfL −0.344 0.079 −0.256 0.198 0.158 0.442 −0.045 0.825
ΔFS −0.433 <0.001 −0.430 <0.001 0.138 0.162 −0.031 0.751

The p-value is based on Spearman’s correlation analysis. p < 0.05 is indicated in bold.

CPET, cardiopulmonary exercise testing; ALS, amyotrophic lateral sclerosis; VO2, oxygen consumption; HR, heart rate; VE, minute ventilation; VCO2, carbon dioxide production; BMI, body mass index; FVC, forced vital capacity; ALSFRS-R, ALS Functional Rating Scale-Revised; UMN, upper motor neuron; LMN, lower motor neuron; KCSS, King’s College Staging System; NfL, neurofilament light chain; ΔFS, (48-[ALSFRS-R])/disease duration from symptom onset to the CPET assessment.