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. 2022 Mar 14;13:872912. doi: 10.3389/fphar.2022.872912

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Copyright © 2022 Wu, Bai, Guo, Guo, Xia, Xia, Gao, Wang, Wu, Dong and Tsim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Capsaicin alleviates UVB-induced increase of MMPs in fibroblasts. The dermal fibroblasts were isolated from postnatal day 2 mice and cultured in vitro. Cells were incubated with capsaicin (Cap) from 1 to 10 μM with or without UVB irradiation at 300 mW/m² at 300 mW/m² for 5 min. The mRNAs of MMP1a, MMP3, and MMP9 were determined using qRT-PCR. Values are in percentage of change against control, in mean ± SD, n = 5, each with triplicate samples. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control (vehicle only).