Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 14;13:872912. doi: 10.3389/fphar.2022.872912

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wu, Bai, Guo, Guo, Xia, Xia, Gao, Wang, Wu, Dong and Tsim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Capsaicin regulates the expression of collagen not through TRPV1 channel. Cultured fibroblasts were treated with capsaicin (1 μM) plus different concentrations of capsazepine (1–10 μM). The mRNAs of (A) MMP1a, MMP3, MMP9 (B) COL1A1, COL1A2, and COL3A1 were determined using qRT-PCR. UVB irradiation (300 mW/m² for 5 min) was applied as a positive control. Values are in percentage of change against control, in mean ± SD, n = 5, each with triplicate samples. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control (vehicle only).