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The IC50 of TKIs on CML cell lines.
| Cell line | TKI IC50, mean ± SD, nM |
|---|---|
| KCL22 | 83 ± 3 (imatinib) |
| KU812 | 51 ± 5 (imatinib) |
| Ba/F3 T315I | 5 ± 0.6 (ponatinib) |
IC50 values were determined using Prism software. Imatinib concentrations at 5, 10, 25, 50, 100, 200 and 400 nM were tested in proliferation assay. Ponatinib concentrations at 0.1, 0.2, 0.5, 1, 2, 4, 8, 16 and 32 nM were tested in proliferation assay. Imatinib was used for KCL22 and KU812. Ponatinib was used for Ba/F3 T315I.
