Table 3.
IC50 values of PI3Kγ, PI3Kδ, and AKT Inhibition of compounds 4d and 7f.
| IC50 (uM)a** |
|||
|---|---|---|---|
| Compounds | PI3Kγ | PI3Kδ | AKT |
| 4d | 35.10 ± 1.82 | 23.90 ± 1.20 | 7.67 ± 0.40 |
| 7f | 6.99 ± 0.36 | 4.01 ± 0.55 | 3.36 ± 0.17 |
| LY294002 | 15.7 ± 0.81 | 13.4 ± 0.67 | – |
| LY2780301 | – | – | 4.62 ± 0.24 |
aIC50 values are the mean ± SD of three separate experiments.
**p < .01.