FIGURE 2.

Cumulative incidence of autoimmune disease comparing individuals suffering from hereditary angioedema (cases) and a background population (controls). All cases and controls (A), men (B), and women (C). Log‐rank test was used to determine statistical significance. (D) Prescription of thyroid hormone substitution among cases and controls, respectively, during the time period 2006–2019. Linear mixed regression models were used in order to account for the dependency over calendar year when studying associations between cases and controls and drug use expressed as proportions over calendar year. An interaction term was fitted to address potential changes in the outcome of interest