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. 2022 Mar 22;20:eRW5686. doi: 10.31744/einstein_journal/2022RW5686

Table 6. Pancreatic enzyme lipase replacement therapy: consensus guidelines(1,4,5,9).

Age Supplementation
Infants (up to 12 months) 2,000-4,000U lipase/120mL of formula or estimated consumption of maternal milk and approximately 2,000U of lipase/g dietary fat in foods
Children aged 1 to 4 years 2,000-4,000U lipase/g of dietary fat, increasing the dose as is necessary (maximum dose of 10,000 lipaseU/kg per day)
Children aged >4 years and adults Consider starting at 500U lipase/kg/meal, titrating up to a maximum dose of: - 1,000-2,500U lipase/kg/meal OR - 10,000U lipase/kg/day OR - 2,000-4,000U lipase/g of dietary fat obtained from all meals, snacks, and beverages containing fat