Table 3.
Correlation analysis between PLIN2 and immune cell infiltrations in OSCC samples using TIMER.
| Description | Gene markers | PLIN2 | |||
|---|---|---|---|---|---|
| None | Purity | ||||
| Cor | p | Cor | p | ||
| CD8+ T cell | CD8A | 0.097 | * | 0.08 | 0.0762 |
| CD8B | 0.152 | *** | 0.135 | ** | |
| T cell (general) | CD3D | 0.099 | * | 0.083 | 0.0651 |
| CD3E | 0.166 | *** | 0.15 | *** | |
| CD2 | 0.165 | *** | 0.148 | ** | |
| B cell | CD19 | 0.158 | *** | 0.15 | *** |
| CD79A | 0.119 | ** | 0.112 | * | |
| Monocyte | CD86 | 0.347 | **** | 0.337 | **** |
| CSF1R | 0.338 | **** | 0.326 | **** | |
| TAM | CCL2 | 0.326 | **** | 0.314 | **** |
| CD68 | 0.291 | **** | 0.27 | **** | |
| IL10 | 0.317 | **** | 0.311 | **** | |
| M1 macrophage | NOS2 | 0.125 | ** | 0.12 | ** |
| IRF5 | 0.135 | ** | 0.127 | ** | |
| PTGS2 | 0.014 | 0.757 | 0.033 | 0.466 | |
| M2 macrophage | CD163 | 0.382 | **** | 0.374 | **** |
| VSIG4 | 0.364 | **** | 0.354 | **** | |
| MS4A4A | 0.376 | **** | 0.363 | **** | |
| Neutrophils | CEACAM8 | 0.085 | 0.052 | 0.086 | 0.0563 |
| ITGAM | 0.396 | **** | 0.386 | **** | |
| CCR7 | 0.283 | **** | 0.284 | **** | |
| Natural killer cell | KIR2DL1 | 0.028 | 0.525 | 0.021 | 0.648 |
| KIR2DL3 | 0.08 | 0.0675 | 0.072 | 0.112 | |
| KIR2DL4 | -0.062 | 0.154 | -0.061 | 0.178 | |
| KIR3DL1 | 0.052 | 0.237 | 0.056 | 0.216 | |
| KIR3DL2 | 0.16 | *** | 0.15 | *** | |
| KIR3DL3 | 0.05 | 0.251 | 0.054 | 0.233 | |
| KIR2DS4 | 0.085 | 0.0535 | 0.091 | * | |
| Dendritic cell | HLA-DPB1 | 0.215 | **** | 0.196 | **** |
| HLA-DQB1 | 0.172 | **** | 0.158 | *** | |
| HLA-DRA | 0.167 | *** | 0.146 | ** | |
| HLA-DPA1 | 0.18 | **** | 0.157 | *** | |
| CD1C | 0.22 | **** | 0.202 | **** | |
| NRP1 | 0.314 | **** | 0.298 | **** | |
| ITGAX | 0.383 | **** | 0.384 | **** | |
| Th1 | TBX21 | 0.174 | **** | 0.16 | *** |
| STAT4 | 0.289 | **** | 0.278 | **** | |
| STAT1 | 0.01 | 0.818 | -0.017 | 0.705 | |
| IFNG | -0.008 | 0.864 | -0.026 | 0.564 | |
| TNF | 0.116 | ** | 0.115 | * | |
| Th2 | GATA3 | 0.194 | **** | 0.184 | **** |
| STAT6 | 0.051 | 0.243 | 0.044 | 0.335 | |
| STAT5A | 0.206 | **** | 0.193 | **** | |
| IL13 | 0.19 | **** | 0.175 | **** | |
| Tfh | BCL6 | 0.243 | **** | 0.248 | **** |
| Th17 | STAT3 | 0.143 | ** | 0.129 | ** |
| IL17A | 0.041 | 0.347 | 0.032 | 0.483 | |
| Treg | FOXP3 | 0.265 | **** | 0.251 | **** |
| CCR8 | 0.283 | **** | 0.265 | **** | |
| STAT5B | 0.367 | **** | 0.352 | **** | |
| TGFB1 | 0.161 | *** | 0.156 | *** | |
| T cell exhaustion | PDCD1 | 0.112 | * | 0.096 | * |
| CTLA4 | 0.184 | **** | 0.173 | *** | |
| LAG3 | 0.078 | 0.076 | 0.067 | 0.136 | |
| HAVCR2 | 0.335 | **** | 0.324 | **** | |
| GZMB | 0.023 | 0.603 | 0.01 | 0.831 | |
TIMER, Tumor Immune Estimation Resource; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. *，**，*** and **** represented that differences were considered statistically significant with P < 0.05, P < 0.01, P < 0.001 and P < 0.0001, respectively.