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. 2022 Mar 16;9:832154. doi: 10.3389/fmed.2022.832154

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Copyright © 2022 Graziadei, De Franceschi, Sainati, Venturelli, Masera, Bonomo, Vassanelli, Casale, Lodi, Voi, Rigano, Pinto, Quota, Notarangelo, Russo, Allò, Rosso, D'Ascola, Facchini, Macchi, Arcioni, Bonetti, Rossi, Sau, Campisi, Colarusso, Giona, Lisi, Giordano, Boscarol, Filosa, Marktel, Maroni, Murgia, Origa, Longo, Bortolotti, Colombatti, Di Maggio, Mariani, Piperno, Corti, Fidone, Palazzi, Badalamenti, Gianesin, Piel and Forni.

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(A) Distribution of sickle cell disease (SCD) patients by age and therapy. Data are shown as a column chart that reports, for each age group, the number of patients that received HC/ATR/CTR/NONE as their therapy regimen. (B) Distribution of the indications for transfusion therapy. Data are shown as counts of the indications for ATR and CTR. ACS, acute chest syndrome; ATR, acute transfusion; CTR, chronic transfusion; HC, hydroxycarbamide; MOFs, multi-organ failures; VOCs, vaso-occlusive events.