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. 2022 Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436

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Copyright © 2022 Foley, Hewes, Garceau, Kotredes, Carter, Sasner and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cortical transcriptome analysis revealed unique functional enrichment for the APOE^ε3/ε4 genotype at 2 months. (A) PCA showed distinct clusters of male and female samples. (B) PCA showed samples do not cluster by APOE genotype at two mos. (C) Number of significant genes for each linear model predictor term (p < 0.05). (D) Number of significant genes unique to 2-month APOE^ε4/ε4 and APOE^ε4/ε4 when compared to APOE^ε3/ε3, as well as the number of significant genes intersecting both lists. (E) Functional enrichment of the 360 significant genes (p < 0.10) unique to APOE^ε3/ε4 compared to APOE^ε3/ε3. (F) Percentage of genes expressed by cell type according to the BrainRNAseq dataset.