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. 2022 Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436

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Copyright © 2022 Foley, Hewes, Garceau, Kotredes, Carter, Sasner and Howell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WGCNA confirmed functional enrichment of GO terms relating to extracellular matrix and morphogenesis is affected by APOE genotype. (A) Heatmap of module correlation and FDR values for sex, APOE genotype, and activity (p < 0.10). (B) Eigengene dendrogram of each module and sex, APOE genotype and activity. Y axis is a measure of dissimilarity. (C,D) Gene significance regressed against module membership to show correlation and significance for the yellow (C) and greenyellow (D) modules for APOE genotype. (E) Functional enrichment of the genes in the greenyellow module which is significant for APOE genotype (p < 0.05).