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. 2022 Mar 21;11(1):2054105. doi: 10.1080/2162402X.2022.2054105

Figure 5.

Figure 5.

STING agonist cGAMP enhanced the therapeutic effect of anti-MSLN CAR-NK-92 cells on pancreatic cancer. (a) Diagram depicting the treatment schedule of STING agonist in combination with anti-MSLN CAR-NK cells in subcutaneous (s.c.) pancreatic tumors of NOD-SCID mice, blue arrows indicate cGAMP treatment, red arrow indicates NK-92 cells or CAR-NK-92 cells treatment, and green arrow indicates IL-2 treatment. (b) Tumor volume was measured with vernier calipers every two or three days. (c) The Violin diagram showing tumors volume measured on day 31. (d) Survival analyses of tumor-bearing mice treated with the indicated control and experimental groups, and were analyzed using Log-rank (Mantel-Cox) test. The statistical significance was determined as ***p < .001, **p < .01 and *p < .05.