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. 2022 Mar 29;98(13):e1304–e1314. doi: 10.1212/WNL.0000000000200017

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Probability of clinically diagnosed Alzheimer disease (AD) dementia proximate to death as a function of the level of AD pathology (summary measure) in participants with low (red, 10th percentile), average (blue, 50th percentile), and high (black, 90th percentile) cognitive resilience index (CRI). For all measures of AD pathology (x-axis), an individual with high CRI (black line) has a lower probability of dementia compared to an individual with low CRI (red).