Figure 1.

Flow diagram of study participants showing number of patients enrolled and analysed and urine collection protocol performance. The study flow diagram outlines the number of patients enrolled in the study, those with available data for analyses, and those with urine successfully collected and measured. At the early visit and late visit, urine specimens for the pre-infusion time point were collected on the day of cisplatin infusion, but before cisplatin administration; post-infusion samples were collected 1 day after cisplatin infusion (in the morning). Samples collected near hospital discharge at the early visit were collected a median (interquartile range) of 3 (2–4) days post-cisplatin infusion, whereas discharge samples at the late visit were collected 2 (2–4) days post-infusion. ^aReasons for specimen noncollection at individual time points at the early visit and the late visit included insufficient quantity, participant refusal, sample misplaced, and protocol error. ^bMissing measurements are due to insufficient quantity of specimen available to measure urine creatinine.