Table 3.
Urine AKI biomarker excretion at early and late cisplatin visits for SCr+eAKI and severe SCr-AKI
| Time Point | n; Median (IQR) | |||
|---|---|---|---|---|
| SCr+eAKI | Severe SCr-AKI | |||
| Non-AKI | AKI | Non-AKI | AKI | |
| Early visit (ng/mg creatinine) | ||||
| Pre-NGAL | 120; 14.4 (6.2–27.5) | 30; 23.8 (7.3–62.3) | 139; 14.5 (6.3–30.4) | 11; 41.6 (11.0–133.5) |
| Post-NGAL | 121; 10.0 (5.3–25.8)a | 27; 23.1 (10.2–115.7) | 138; 12.1 (5.6–28.7) | 10; 20.7 (8.70–136.7) |
| Discharge NGAL | 119; 13.1 (5.5–38.5)b | 27; 58.7 (16.5–96.2) | 136; 15.4 (6.7–47.2) | 10; 47.6 (3.8–184.8) |
| Late visit (ng/mg creatinine) | ||||
| Pre-NGAL | 106; 14.3 (5.5–34.3) | 14; 35.7 (5.3–91.2) | 113; 13.7 (5.3–38.5)c | 7; 36.7 (12.7–170.1) |
| Post-NGAL | 108; 11.9 (5.2–29.6) | 15; 23.6 (8.8–187.1) | 116; 11.5 (5.2–28.4)a | 7; 57.2 (23.6–407.8) |
| Discharge NGAL | 101; 15.1 (5.6–30.1)c | 15; 53.8 (7.4–279.9) | 109; 14.9 (5.6–30.8)a | 7; 174.7 (53.8–279.9) |
| Early visit (pg/mg creatinine) | ||||
| Pre–KIM-1 | 120; 397 (185–812) | 30; 376 (167–1563) | 139; 397 (185–836) | 11; 249 (157–3420) |
| Post–KIM-1 | 121; 225 (155–569) | 27; 315 (167–3147) | 138; 240 (167–610) | 10; 301 (91–2585) |
| Discharge KIM-1 | 119; 1468 (374–3703) | 27; 2019 (458–5696) | 136; 1526 (403–3846) | 10; 1984 (307–4343) |
| Late visit (pg/mg creatinine) | ||||
| Pre–KIM-1 | 106; 505 (202–1085) | 14; 580 (185–1818) | 113; 483 (192–1001)c | 7; 1571 (533–5771) |
| Post–KIM-1 | 108; 337 (185–924) | 15; 357 (257–1549) | 116; 334 (185–839)a | 7; 1549 (357–18974) |
| Discharge KIM-1 | 101; 1108 (421–3389)c | 15; 4079 (2069–10546) | 109; 1253 (428–3757)a | 7; 8240 (3204–12957) |
SCr+eAKI; composite outcome of SCr-AKI and electrolyte-AKI; SCr-AKI, serum creatinine–defined AKI; IQR, interquartile range; Pre-, preinfusion; NGAL, neutrophil gelatinase-associated lipocalin; Post-, postinfusion; discharge, hospital discharge; KIM-1, kidney injury molecule-1.
a
P<0.01, significant difference between AKI and non-AKI groups for that time point.
b
P<0.001, significant difference between AKI and non-AKI groups for that time point.
c
P<0.05, significant difference between AKI and non-AKI groups for that time point.