Table 5.
Histologic predictors of KFI: univariate and multivariate analysis
| Histogic Features | Univariate Analysis | Multivariate Analysis 1 | Multivariate Analysis 2 | |||
|---|---|---|---|---|---|---|
| Odds Ratio (95% Confidence Interval) | P Value | Odds Ratio (95% Confidence Interval) | P Value | Odds Ratio (95% Confidence Interval) | P Value | |
| Histologic classes III+IV versus II+V | 1.68 (0.77 to 3.68) | 0.20 | ||||
| Histologic class IV versus all of the other classes | 1.95 (1.01 to 3.78) | 0.05a | ||||
| Activity index ≤6 versus >6 | 1.08 (0.57 to 2.04) | 0.81 | ||||
| Endocapillary hypercellularityb | 1.14 (0.58 to 2.22) | 0.71 | ||||
| Neutrophil infiltrationb | 1.13 (0.55 to 2.32) | 0.74 | ||||
| Hyaline deposits/wire loopsb | 0.62 (0.32 to 1.19) | 0.15 | ||||
| Cellular/fibrocellular crescentc | 1.73 (0.81 to 3.67) | 0.16 | ||||
| Fibrinoid necrosis/ karyorrhexisc | 0.62 (0.28 to 1.35) | 0.23 | ||||
| Interstitial inflammationb | 2.21 (1.15 to 4.27) | 0.02a | ||||
| Interstitial inflammation in normal T-I areasb | 0.74 (0.33 to 1.69) | 0.68 | ||||
| Interstitial inflammation in presence of chronic T-I lesionsb | 3.15 (1.65 to 6.02) | <0.001a | ||||
| Neutrophil infiltration/ karyorrhexisb | 1.15 (0.56 to 2.37) | 0.39 | ||||
| Fibrinoid necrosisc | 0.48 (0.17 to 1.35) | 0.16 | ||||
| Chronicity index ≤2 versus >2 | 3.98 (2.08 to 7.62) | <0.001a | ||||
| Glomerulosclerosisc | 4.88 (2.49 to 9.54) | <0.001a | 3.05 (1.17 to 7.92) | 0.02 | 3.94 (1.84 to 8.43) | <0.001 |
| Fibrous crescentsc | 7.00 (3.43 to 14.26) | <0.001a | 6.84 (3.22 to 14.52) | <0.001 | 5.77 (2.57 to 12.94) | <0.001 |
| Tubular atrophyc | 9.30 (4.30 to 20.1) | <0.001a | 3.17 (1.04 to 9.64) | 0.04 | ||
| Interstitial fibrosisc | 7.27 (3.68 to 14.37) | <0.001a | 2.36 (1.05 to 5.32) | 0.038 | ||
| Extraglomerular deposits d | 2.00 (1.04 to 3.86) | 0.04a | ||||
| Tubular depositsd | 1.14 (0.60 to 2.16) | 0.69 | ||||
| Interstitial capillary wall depositsd | 1.69 (0.66 to 4.35) | 0.27 | ||||
| Vascular depositsd | 2.44 (1.27 to 4.68) | 0.007a | ||||
Likelihood ratio test used for multivariate analysis 1 (46.25 on 3 df; P<0.001) and for multivariate analysis 2 (46.17 on 3 df; P<0.001). KFI, kidney function impairment; T-I, tubulointerstitial.
a
P≤0.05.
b
These variables were categorized as 0 versus 1+2+3; where 0 scored if absent; 1+ if mild (in <25% of glomeruli and/or in tubulointerstitial cortex); 2+ if moderate (between 25% and <50% of glomeruli and/or in tubulointerstitial cortex); and 3+ if severe (in >50% of glomeruli and/or in tubulointerstitial cortex).
c
These variables were categorized as 0+1 versus 2+3.
d
These variables were categorized as present or absent.