Table 6.
Clinical and histologic predictors of KFI: uUnivariate and multivariate analysis
| Predictors | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| Odds Ratio (95% Confidence Interval) | P Value | Odds Ratio (95% Confidence Interval) | P Value | |
| Clinical predictors of KFI | ||||
| Serum creatinine, mg/dl | 1.91 (1.56 to 2.33) | <0.001 | 1.79 (1.45 to 2.22) | <0.001 |
| Creatinine clearance, ml/min | 0.98 (0.97 to 0.99) | <0.001 | ||
| Arterial hypertension | 8.62 (3.67 to 20.26) | <0.001 | 6.15 (2.60 to 14.58) | <0.001 |
| Hematocrit, % | 0.93 (0.88 to 0.98) | 0.005 | ||
| Serositis | 2.42 (1.23 to 4.77) | 0.01 | ||
| Months from LN onset to kidney biopsy | 1.01 (1.00 to 1.01) | 0.02 | ||
| Clinical and histologic predictors of KFI | ||||
| Serum creatinine, mg/dl | 1.68 (1.31 to 2.15) | <0.001 | ||
| Arterial hypertension | 4.64 (1.90 to 11.32) | <0.001 | ||
| Glomerulosclerosisa | 2.12 (1.00 to 4.50) | 0.05 | ||
| Fibrous crescentsa | 5.18 (2.43 to 11.04) | <0.001 | ||
| Months from LN onset to kidney biopsy | 1.01 (1.00 to 1.01) | 0.03 | ||
KFI, kidney function impairment; LN, lupus nephritis.
a
The histologic variables were categorized as 0 + 1 versus 2 + 3; where 0 is scored if absent; 1+ if mild (in <25% of glomeruli and/or in tubulointerstitial cortex); 2+ if moderate (between 25% and <50% of glomeruli and/or in tubulointerstitial cortex); and 3+ if severe (in >50% of glomeruli and/or in tubulointerstitial cortex).