U-sed pod mRNA, but not u-sup P CX was significantly correlated with the rate of crescent formation in IgAN and Cres GN. (A) u-sed Pod mRNA excretion and u-sup PCX protein in the Oxford IgAN histologic classification (M0, n=35; M1, n=25; E0, n=25; E1, n=35; S0, n=26; S1, n=34; T0, n=50; T1 and 2, n=10; C0, n=31; C1 and 2, n=29). u-sed Pod mRNA excretion, but not u-sup PCX protein, was significantly increased in the presence of extracapillary proliferative lesions. (B) Relationship between u-sed Pod mRNA excretion and rate of crescent formation in crescentic GN (Cres GN). (C) Relationship between u-sup PCX protein and rate of crescent formation in Cres GN. u-sed Pod mRNA excretion, but not sup-PCX protein, was significantly correlated with the rate of crescent formation (u-sed Pod mRNA excretion: n=17, r=0.56, P=0.02; u-sup PCX protein: n=17, r=−0.12, P=0.65). *P<0.05 by Mann–Whitney U test. Cr, creatinine.