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. 2021 Nov 5;3(1):28–36. doi: 10.34067/KID.0005522021

Figure 2.

Figure 2.

Enrichment of damage-related pathways in cells from patients with AKI. Gene Set Enrichment Analysis of each cluster of cells from the integrated UMAP for pathways, including (A) hallmark reactive oxygen species pathways, (B) hallmark apoptosis pathways, and (C) hallmark DNA repair pathways in patients with COVID-19 AKI (left panels), COVID-19 no AKI controls (center panels), and patients with non–COVID-19 AKI (right panels). Cluster identifications are as follows: 1, urothelial; 2, urothelial; 3, urothelial; 4, macrophage; 5, MHC class 2–positive neutrophil; 6, loop of Henle; 7, neutrophil; 8, collecting duct; 9, urothelial; 10, umbrella; 11, neutrophil; 12, collecting duct; 13, kidney resident macrophage; 14, neutrophil; 15, urothelial; 16, cycling; 17, proximal tubule; 18, proximal tubule; 19, smooth muscle cell; 20, intercalated cell; 21, urothelial; 22, T cell; 23, podocyte; 24, red blood cell; 25, macrophage; 26, B cell; 27, macrophage; 28, red blood cell.