Table 1.
Patient characteristics pre- and postmatch
| Recipient Variables (Matched) | Patients on Remdesivir Prematch, N=34 | Controls Prematch, N=217 | Patients on Remdesivir Postmatch, N=31 | Controls Postmatch, N=31 | Standard Differencea |
|---|---|---|---|---|---|
| Age, yr, mean (SD) | 70.2 (16.5) | 74.6 (13.2) | 71.4 (16.6) | 72.0 (15.3) | −0.0382 |
| Women | 22 (64.7%) | 120 (55.3%) | 21 (67.7%) | 17 (54.8%) | 0.2673 |
| White race | 17 (50.0%) | 153 (70.5%) | 16 (51.6%) | 14 (45.2%) | 0.1294 |
| SOFA score, mean (SD) | 6.5 (2.4) | 7.8 (3.7) | 6.6 (2.5) | 6.3 (2.9) | 0.1311 |
| Admission creatinine, mg/dl, mean (SD)b | 3.1 (2.4) | 2.9 (1.7) | 3.2 (2.5) | 3.2 (2.7) | −0.0030 |
| Hypertension | 32 (94.1%) | 192 (88.5%) | 29 (93.5%) | 30 (96.8%) | −0.1508 |
| Diabetes mellitus | 29 (85.3%) | 138 (63.6%) | 26 (83.9%) | 26 (83.9%) | 0 |
| ESKD | 14 (41.2%) | 50 (23%) | 13 (41.9%) | 10 (32.3%) | 0.2013 |
| SOT | 4 (11.8%) | 5 (2.3%) | 2 (6.5%) | 2 (6.5%) | 0 |
| Mechanical ventilation within first 72 h | 7 (20.6%) | 68 (31.3%) | 7 (22.6%) | 7 (22.6%) | 0 |
Each remdesivir-treated patient was matched 1:1 with a potential comparator who was admitted in March or April 2020 prior to the emergency use authorization of remdesivir. The results presented here are the means (SDs) or counts (percentages). SOFA, sequential organ failure assessment; SOT, solid organ transplant.
A standardized (mean) difference is a measure of distance between two group means in terms of a variables and is a conventional metric used to evaluate the quality of a match. By convention, a standardized mean difference of <0.1 is considered a well-balanced covariate.
Admission creatinine for patients not on dialysis only. For patients on KRT prior to baseline, a baseline creatinine of 10 mg/dl was imputed for the purpose of matching.