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. 2022 Mar 23;603(7903):871–877. doi: 10.1038/s41586-022-04510-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a. UMAP projection of NKX2-1/CRABP1+/ETV1+ cells only colored by scaled and normalized expression of TAC3 or MAF class markers. b. Allen Institute E15.5 mouse brain in situ hybridization showing expression of CRABP1+ neuron-related regional transcription factors. Green circle denotes boundary between Lhx8+ MGE and rostroventral MGE/septum known to produce cholinergic neurons and the Etv1+ MGE thought to produce CRABP1+ striatal interneurons, indicating partitioning of Etv1 and Lhx8 domains in mouse MGE. c. SCENIC module scores (Y-axis) vs log2 fold change of hub transcription factor predicted to regulate the module (X-axis). Significance represents multiple testing corrected q-value < 0.1 for both diffxpy differential expression in macaque and also q-value < 0.1 SCENIC logistic regression coefficient q-value calculated by shuffling class labels. Size represents the proportion of all CRABP1+ cells which also express the gene. d. UMAP projection showing the region from which macaque cells are derived. e. UMAP projection showing classes in cells expressing 2 or more of (CRABP1, ETV1, ANGPT2). f. Subclustering of rare NKX2-1+ cells from organoid dataset⁵⁸, labeled by Leiden subclusters. g. NKX2-1+ cells from organoid dataset⁵⁸, labeled by the experimental conditions of the differentiation. h. Dotplot of expression of MGE_CRABP1 related markers in Leiden subclusters showing cluster 6 likely contains MGE_CRABP1/MAF and MGE_CRABP1/TAC3 cells.