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. 2022 Mar 23;603(7903):871–877. doi: 10.1038/s41586-022-04510-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — a. Medial sagittal section of PCD80 macaque brain. The SCGN+ RMS originating at the anterior pole of the dLGE is seen extending from the olfactory ventricle to the OB. b. FOXP2+/PAX6+ cells from lateral migratory streams converge with RMS and enter periglomerular layers of OB (see also Extended Data Fig. 1). Note that FOXP2+ OB-PGC_FOXP2/CALB1 cells are largely absent from the RMS but are found ventral of the nucleus accumbens (NAc), anterior olfactory nucleus (AON) and in outer olfactory tract sheath. c. SCGN+/PAX6+ granule cells (OB-GC_MEIS2/PAX6) (cyan arrows), TH+ PGCs (OB-PGC_TH/SCGN) (yellow arrows) and FOXP2+ PGCs (OB-PGC_FOXP2/CALB1) (blue arrows) in OB. d–f. Human gestation week 20.5 sagittal cortex section shows new-born FOXP2+/SCGN+/PROX1- neurons (blue arrows) migrating into the ventral cortex superficial white matter. SCGN+ expression decreases as cells mature. g. Lateral sagittal section of PCD80 macaque brain. h. Immunofluorescence FOXP2+/FOXP4+/SCGN+ dLGE-derived projection class neurons (blue arrows) are seen in large numbers in the dLGE portion dorsal of the caudate, and in adjacent cortical white matter and striatum. i. 7 month old macaque coronal section. j. Montage from box in i with rare DLX2/FOXP2+ superficial white matter IN (SWMIN) marked with a blue arrow.