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. 2022 Mar 23;603(7903):871–877. doi: 10.1038/s41586-022-04510-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 13 — a. Low magnification stitching of oblique horizontal section showing large stream of MEIS2+/SCGN+ chains in the Arc along the dorsomedial edge of the TH+ striatum. b. Further dorsal oblique horizontal section showing dorsal and lateral migratory streams. c. Enlargement of Arc-ACC. Cyan arrows denote MEIS2+/SCGN+ dLGE cells. Note that the stream is continually bounded by the increased density of TH+ fibers. d. Chains caudal of the striatum are of mixed classes. e. White matter neurons lateral of the striatum are nearly all MEIS2-negative (green arrows). Also note peristriatal SP8+/MEIS2+/TH+ striatum laureatum neurons (SLNs) at lateral border of striatum (yellow arrows). f. Coronal section of PCD120 macaque striatum showing an array of TH+ peristriatal SLNs(yellow arrows) at the edge of the caudate nucleus, from Fig. 3b, at the same location as 7 month postnatal, but not yet having developed SCGN+/TH+ processes tangential to the external capsule. g, h. Coronal section of PCD120. Sparse MKI67+ cells at ventricle, with SCGN+ cells away from the ventricle being MKI67-. i, j. Chains in Arc do not appear to be MKI67+. k. PCD120 SCGN/TH+ peristriatal SLNs (yellow arrows) are NR2F2 negative (NR2F2+ DWMINs labeled with green arrows). Note that the LGE_MEIS2/PAX6 and LGE_FOXP2/TSHZ1 classes very sparsely expressed the transcript encoding tyrosine hydroxylase (TH), a rate limiting enzyme in dopamine production, and were the only cortical IN classes to do so at developmental stages (see Fig. 4b). l. Coronal section of macaque cortex at 7 months. m. PAX6+/SCGN+/NR2F2- deep white matter neurons in postnatal macaque cingulate cortex (cyan arrows). These DWMINs were found in the cingulate white matter and corona radiata, though not in the corpus callosum itself and rarely near the deep layers of the cortical plate and external capsule white matter.