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. 2022 Mar 23;603(7903):871–877. doi: 10.1038/s41586-022-04510-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a. Heatmap of mouse initial class marker genes selected from the top markers of each, scaled by column. b. Scatterplots of log 2 fold changes of each initial class vs the rest of the dataset for mouse vs macaque, with selected gene families of interest labeled. Conserved represents genes significantly upregulated in class vs rest in both species, Mouse-specific in mouse but not macaque, etc. N.S.= Not Significant in either species. Significance defined as |log2fc| > 1.2 and adjusted p value < .01, with significance marked "signif" in Supplementary Table 3. MGE_CRABP1/TAC3* is the comparison of macaque MGE_CRABP1/TAC3 vs mouse MGE_CRABP1/MAF, as this is the ancestral class comparison. Note that more genes show specific correlations to the macaque MGE_CRABP1/TAC3 class versus the macaque MGE_CRABP1/MAF class in the comparison to the single mouse MGE_CRABP1/MAF class. c. Pairwise Pearson correlations of mean gene expression in classes across species.