Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibitory effects of fluoroquinolones on S. pneumoniae gyrase and topoisomerase IV and on growth of S. pneumoniae 7785
| Quinolone | IC50 (μM) for:
|
MIC (μM) | |
|---|---|---|---|
| DNA supercoiling by DNA gyrase | kDNA decatenation by topoisomerase IV | ||
| NSFQ-105 | 5–10 | 20 | 0.13–0.26 |
| Ciprofloxacin | 80 | 5 | 2.7 |
