Table 2.
Comparison of specific types of dysplastic morphologic features of myelodysplastic/ myeloproliferative neoplasms unclassifiable with and without isolated i(17q)
| MDS/MPN-U with iso(17q) | MDS/MPN-U without i(17q) | P | MDS/MPN-U with iso(17q) | MDS/MPN-U without i(17q) | P | |
|---|---|---|---|---|---|---|
| LINEAGE | >10%/ ≥1 | >50%/ ≥3 | ||||
| ERYTHROID | ||||||
| Megaloblastoid changes | 6/8 | 9/13 | 1 | 0/8 | 2/13 | .5048 |
| Multinucleation | 0/8 | 0/13 | 1 | 0/8 | 0/13 | 1 |
| Nuclear contour irregularities | 3/8 | 5/13 | 1 | 0/8 | 0/13 | 1 |
| Pyknosis | 0/8 | 2/13 | .505 | 0/8 | 0/13 | 1 |
| Ring Sideroblasts | 1/8 | 3/13 | 1 | 0/8 | 2/13 | .5048 |
| MYELOID | ||||||
| Abnormal nuclear shape | 6/8 | 5/13 | .183 | 3/8 | 1/13 | .3002 |
| Pseudo-Pelger Huet nuclei | 6/8 | 3/13 | .032 | 3/8 | 0/13 | .0815 |
| Cytoplasmic hypogranulation | 6/8 | 12/13 | .531 | 2/8 | 2/13 | .5308 |
| MEGAKARYOCYTIC | ||||||
| Micromegakaryocytes | 2/8 | 1/12 | .537 | 0/8 | 0/12 | 1 |
| Hypolobated/ monolobated nuclei | 5/8 | 2/10 | .062 | 0/8 | 0/12 | 1 |
| Separated nuclear lobes | 1/8 | 3/12 | .642 | 0/8 | 1/12 | 1 |
MDS/MPN-U, myelodysplastic/ myeloproliferative neoplasm-unclassified; iso(17q), isochromosome (17q)