TABLE 4.

EMB-resistant M. tuberculosis isolates with mutations in two or more genes

Isolate	MIC (μg/ml)	Mutationa
		embC	embA	embB	Rv3124	Rv0340	iniB	iniA	iniC	rmlA2
TN2050	>50			Q497K			89 UPS, C→T
TN2946	40			G745D				G308R
TN4864	30		12 UPS, C→T	Q497K
TN5480	20			M306I						D152N
TN5534	40	R738Q	16 UPS, C→T	M306I	P54S
TN6980	40		D4N	G406D
TN7289	50	N394D	G350D		L276R	24 UPS, G del
			P913S
TN8199	20		43 UPS, CG del	M306I
TN8560	30		12 UPS, C→T	Q497R				S501W
TN8561	30		43 UPS, CG del	G406S
TN8564	>10		16 UPS, C→G					S501W
TN8565	5							S501W	P248A
TN8568	30			M306I				S501W
TN8575	30		12 UPS, C→T	M1000R
TN8708	10			M306I	16 UPS, A→G
HN56	40		P913S						Q351STOP
NHN203	30		A201T	D328Y
				Y334H
TN718	20		11 UPS, C→A	M306I
				G406A
TN1618	20		G5S	M306I

^aThe single-letter amino acid designations used are as follows: A, alanine; D, aspartic acid; G, glycine; H, histidine; I, isoleucine; K, lysine; L, leucine; M, methionine; N, asparagine; P, proline; Q, glutamine; R, arginine; S, serine; T, threonine; W, tryptophan; and Y, tyrosine. The single-letter nucleotide designations used are as follows: A, adenine; C, cytosine; G, guanine; and T, thymidine. The other abbreviations are as follows: UPS, nucleotide position upstream of the start codon; del, deletion of the nucleotide bases; STOP, termination mutation.