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. 2022 Mar 30;12:5377. doi: 10.1038/s41598-022-09458-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Naïve, effector and exhausted CD8 T cell enrichment scores in CCR8-high and CCR8-low lung tumors. Whole tumor mRNA expression data of patients with adenocarcinoma (n = 510) and squamous cell carcinoma (n = 484) were obtained from TCGA cBioPortal database. Patients were divided into high and low CCR8 groups based on the median CCR8/PTPRC ratio. Gene Set Variation Analysis (GSVA) was performed with naïve, effector and exhausted CD8 T cell signature genes, as described by Guo et al., and the calculated GSVA enrichment scores in CCR8-high and low group are shown. Statistical analysis significance was determined by unpaired t-test with Welch’s correction (*p ≤ 0.05; **p < 0.01; ***p < 0.001).