Table 2.
Patient characteristics for fungal genetic and phenotype analysis.
| General characteristics | IBS-H | IBS-N | HV | |
|---|---|---|---|---|
| n = 17 | n = 16 | n = 16 | ||
| Age | mean ± SD years | 39.8 ± 19.7 | 52.6 ± 18.3 | 44.7 ± 15.5 |
| Sex | n (% females) | 13 (76.5%) | 12 (75.0%) | 8 (50.0%) |
| Body Mass Index | mean ± SD kg m-2 | 24.0 ± 4.7 | 25.0 ± 4.0 | 24.4 ± 5.1 |
| IBS subtype | IBS-C | 5 (29.4%) | 4 (25.0%) | – |
| IBS-D | 4 (23.5%) | 7 (43.8%) | – | |
| IBS-M | 8 (47.1%) | 2 (25.0%) | – | |
| IBS-U | 0 (0.0%) | 1 (6.3%) | – | |
| Symptoms and sensitivity | mean ± SD | |||
| Mean composite symptom scorea | 20.5 ± 5.2 | 16.3 ± 4.1 | 9.9 ± 1.2 | |
| Discomfort | 2.9 ± 0.8 | 2.2 ± 0.7 | 1.1 ± 0.2 | |
| Pain | 2.7 ± 0.8 | 1.9 ± 0.6 | 1.1 ± 0.1 | |
| Nausea | 2.3 ± 1.2 | 1.6 ± 0.6 | 1.10 ± 0.0 | |
| Bloating | 2.4 ± 0.7 | 2.0 ± 0.9 | 1.1 ± 0.2 | |
| Flatulence | 2.3 ± 1.0 | 2.3 ± 1.0 | 1.3 ± 0.4 | |
| Belching | 1.8 ± 0.8 | 1.4 ± 0.6 | 1.1 ± 0.3 | |
| Constipation | 1.7 ± 0.7 | 1.3 ± 0.5 | 1.1 ± 0.1 | |
| Diarrhea | 1.6 ± 0.7 | 1.3 ± 0.3 | 1.0 ± 0.1 | |
| Overall symptom burden | 2.8 ± 0.8 | 2.3 ± 0.6 | 1.1 ± 0.2 | |
| Max VAS score for discomfort 0–26 mmHg distensionb | mean ± SD | 21.1 ± 20.7 | 38.2 ± 30.8 | 17.7 ± 17.3 |
| Max VAS score for pain 0–26 mmHg distensionb | mean ± SD | 50.7 ± 23.3 | 5.3 ± 5.9 | 1.3 ± 2.3 |
Patients recruited from Maastricht IBS (MIBS) study cohort.
aComposite score calculated based on 14-day mean of 9 subjects scored on a 5-point Likert scale. Each subject was scored from 1 to 5 (i.e. abdominal discomfort, abdominal pain, nausea, bloating, flatulence, belching, constipation, diarrhea, symptom burden). Composite score range 9–45.
bMaximum VAS for pain 0–26 mmHg ≥ 20 mm is considered as hypersensitive to colorectal distension.