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. 2022 Mar 30;13:1702. doi: 10.1038/s41467-022-28871-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The distribution of the log₂ termination efficiency (see Methods) for each Rho-dependent terminator in WT, Rho^D210G and Rho^L187R strains (left panel). Meta-analysis of the average readthrough past Rho-dependent termination sites in WT, Rho^D210G and Rho^L187R strains. The dashed line represents the termination site (right panel). b Scatterplots comparing the NTS RPKM (RNA-seq) in WT vs Rho^L187R (top) or Rho^D210G (bottom) mutants. Genes are colored based on their fold increase in the Rho mutant compared to WT. Blue genes had a greater than 4-fold increase in antisense transcription and yellow genes had a 2-4-fold increase in antisense transcription. c The recovery of TT-CPD lesions in WT, Rho^D210G, and Rho^L187R strains (****p < 10⁻⁷⁷). The box shows the interquartile range (IQR), the line shows the median, and the whiskers extend to 1.5xIQR. The top of the box represents the 75th percentile and bottom represents the 25th percentile. n denotes the number of genes in each plot. P-values were calculated using a paired Wilcoxon signed rank test.