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. 2022 Mar 30;13:1678. doi: 10.1038/s41467-022-29160-4

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pooled analysis: data analysis based on the pooled individual patient data; Meta-analysis: statistical analysis by combining the effect size and standard error estimates from different sites; The proposed DLMM algorithm: the distributed linear mixed model algorithm.