Figure 2.
ALDH inhibitors significantly reduced ALDH activity; disulfiram reduced activity significantly more than NCT-505 and -506. ALDH activity after treatment with calculated viability IC50 of NCT-505, NCT-506, and disulfiram determined in (A) OV90 and (B) OVCAR3 TICs via flow cytometry following ALDEFLUOR protocol. Graphs represent mean and SEM of each treatment, from 3 independent experiments, ∞, compared to all groups, *p <0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, compared to vehicle control.