TABLE 2.

Risk of bias (RoB) assessments by domain (N = 250).

Domain	Risk of bias assessment N (%)
	High	Unclear	Low
Sequence generation	33(13.2%)	68(27.2%)	149(59.6%)
Allocation concealment	24(9.6%)	51(20.4%)	175(70.0%)
Blinding: participant and personnel	11(4.4%)	112(44.8%)	127(50.8%)
Blinding: outcome assessor	11(4.4%)	33 (13.2%)	206(82.4%)
Incomplete outcome data	8(3.2%)	57(22.8%)	185(74.0%)
Selective reporting	26(10.4%)	67(26.8%)	157(62.8%)
Other bias	36(14.4%)	106(42.4%)	108(42.8%)
Overall RoB	78(31.2%)	99(39.6%)	73(29.2%)