TABLE 4.
Risk of bias assessments by domain in studies funded by the industry or non-industry (N = 250).
| RoB domain | Funding source (industrial vs. non-industrial) |
||||
| Industrial | N (%) | Non- industrial |
N (%) | p-value | |
| Random sequence generation | Low Unclear High |
66 (62.3) 32 (30.2) 8 (7.5) |
Low Unclear High |
71 (59.7) 33 (27.7) 15 (12.6) |
0.4533 |
| Allocation concealment |
Low Unclear High |
90 (84.9) 13 (12.3) 3 (2.8) |
Low Unclear High |
76 (63.9) 32 (26.9) 11 (9.2) |
0.0014* |
| Blinding: participant and personnel | Low Unclear High |
70 (66.0) 35 (33.0) 1 (0.94) |
Low Unclear High |
51 (42.9) 61 (51.3) 7 (5.9) |
0.0001* |
| Blinding: outcome assessor | Low Unclear High |
95 (89.6) 8 (7.5) 3 (2.8) |
Low Unclear High |
95 (79.8) 19 (16.0) 5 (4.2) |
0.1198 |
| Incomplete outcome data | Low Unclear High |
86 (81.1) 14 (13.2) 6 (5.7) |
Low Unclear High |
91 (76.5) 25 (21.0) 3 (2.5) |
0.1734 |
| Selective reporting | Low Unclear High |
80 (75.5) 23 (21.7) 3 (2.8) |
Low Unclear High |
86 (72.3) 29 (24.4) 4 (3.4) |
0.8598 |
| Other bias | Low Unclear High |
55 (51.9) 41 (38.7) 10 (9.4) |
Low Unclear High |
47 (39.5) 56 (47.1) 16 (13.4) |
0.1659 |
| Overall RoB | Low Unclear High |
42 (39.6) 41 (38.7) 23 (21.7) |
Low Unclear High |
30 (25.2) 53 (44.5) 36 (30.3) |
0.0587 |
Statistical analysis was made by regression analysis. *Statistically significant results (p < 0.001).