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. 2022 Mar 17;13:829366. doi: 10.3389/fimmu.2022.829366

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Copyright © 2022 Yang, Li, Piao, Liu, Wei, Sang, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed genes between NKTCL patients with high and low expression of CD56. (A) Heatmap shows the differentially expressed genes among groups, which were determined by significance criteria (abs(log2FC)>1 and adjusted P value<0.05) as implemented in the R package limma. The heatmap was drawn by pheatmap R package according to the differentially expressed genes. Unsupervised analyzing and hierarchical clustering of common differentially expressed genes based on expression data. (B) Gene annotation enrichment analysis using the clusterProfiler R package was performed on signature genes. The top five pathways with the greatest enrichment were Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Natural killer cell mediated cytotoxicity, Wnt signaling pathway.