Table 4.

Results of univariate and multivariate analyses of prognostic factors for OS and PFS in patients with Stage I/II.

Parameter	OS			PFS
	Univariate analysis	Multivariate analysis		Univariate analysis	Multivariate analysis
	P-value	RR (95% CI)	P-value	P-value	RR (95% CI)	P-value
Age > 60 years	< 0.0001*	2.604(1.675–4.065)	< 0.000*	0.005*	1.812(1.217-2.695)	0.003*
Gender, male	0.024*			0.491
ECOG PS ≥ 2	< 0.0001*	1.672(1.092-2.564)	0.018*	< 0.0001*	1.730(1.200-2.494)	0.003*
Subtype, Extra UAT	0.471			0.292
B symptoms	0.146			0.341
Priamry tumor invasion	< 0.0001*	1.761(1.167-2.653)	0.002*	< 0.0001*	1.595(1.134-2.242)	0.001*
Extranodal sites ≥ 2	0.681			0.823
Regional lymphadenopathy	0.042*	1.437(0.953-2.165)	0.083	0.002*	1.543(1.092-2.183)	0.014*
Elevated serum LDH	0.038*			0.026*
CD 56- negative	0.008*	1.451(0.975–2.160)	0.067	0.005*	1.786 (1.250–2.551)	0.024*

OS, overall survival; PFS, progression-free survival; RR, relative risk; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; Extra UAT, extraupper aerodigestive tract; LDH, lactate dehydrogenase; IPI, International Prognostic Index; KPI, Korean Prognostic Index.

*Indicates statistically significant.