Table 1.

List of interacting molecules within lung cancer cell of non-smokers.

Interacting pair	Secreted	Annotation_strategy	Significant_means*	P-values**
CD74 : APP	No	Curated	10.1916	<0.001
CEACAM6 : CEACAM6	No	Curated	9.9630	<0.001
CD74 : MIF	Yes	I2D, InnateDB-All	9.8360	<0.001
CD74 : COPA	Yes	IMEx, IntAct	9.4922	<0.001
ICAM1 : AREG	Yes	InnateDB-All	7.5263	<0.001
EGFR : AREG	Yes	Curated	6.6550	<0.001
CEACAM5 : CEACAM6	No	Curated	6.4427	<0.001
CD55 : ADGRE5	Yes	Curated	6.3808	<0.001
CXCL2 : DPP4	Yes	Curated	3.1502	<0.001
CADM1 : CADM1	No	Curated	2.4790	<0.001
LGALS9 : CD47	Yes	InnateDB-All	2.2030	<0.001
EFNA1 : EPHA2	Yes	Curated	1.9217	<0.001
CD44 : HBEGF	Yes	I2D, InnateDB-All	1.9061	<0.001
EGFR : GRN	Yes	InnateDB-All	1.8111	<0.001
EGFR : MIF	Yes	IMEx, InnateDB-All	1.7214	<0.001

*Significant_means denotes the significant mean calculation for all the interacting partners. If P < 0.05, the value will be the mean; alternatively, the value is set to 0²².

** P values for all the interacting partners: p-value refers to the enrichment of the interacting ligand-receptor pair in each of the interacting pairs of cell types²².