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. 2022 Mar 29;20:101404. doi: 10.1016/j.tranon.2022.101404

Fig. 1.

Fig 1

Activation of cGAS-STING pathway potentiates tumorigenesis. (A) Representative images of immunofluorescence staining of γH2AX and cGAS in pancreatic tumor tissues and matched normal tissue. Scale bar: 50 μm. (B) Representative images of immunofluorescence staining of γH2AX and cGAS in different tumor cell lines. Scale bar: 50 μm. (C) Knockout effect of cGAS or STING in HeLa, MCF-7 and PANC-1 cells. (D, E) Tumor growth curve of the tumor-bearing mice injected with negative control (NC), cGAS-/- and STING-/- HeLa or MCF-7 cells. 5 mice were used for each group. (F) The mRNA expression of cGAS and STING in pancreatic tumor tissues (GSE16515, GSE15471), breast tumor tissue (GSE3744) were compared with those of normal tissues. Data were represented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.