Table 4.
Microorganisms detected in 525 children and adolescents with community acquired pneumonia and 61 controls, by mPCR, UA, IFA and acute serology IgM for M. pneumoniae
| Microorganism, diagnostic test | CAP group (N = 525) n (%) |
Control group (N = 61) n (%) |
|---|---|---|
| Streptococcus pneumoniae: | ||
| mPCR | 435 (82.9) | 30 (49.2) |
| UAa | 92 (17.9) | 4 (8) |
| Haemophilus influenzae. mPCR | 359 (68.4) | 32 (52.5) |
| Respiratory syncytial virus A and B: | ||
| IFA | 39 (7.4) | 4 (6.5) |
| mPCR | 111 (21.1) | 5 (8.2) |
| Parainfluenza virus 1, 2, 3, 4: | ||
| IFA | 33 (6.3) | 6 (9.8) |
| mPCR | 68 (12.9) | 6 (9.8) |
| Rhinovirus A/B/C. mPCR | 111 (21.1) | 6 (9.8) |
| Influenza A and B: | ||
| IFA | 12 (2.3) | 2 (3.3) |
| mPCR | 47 (8.9) | 5 (8.2) |
| Mycoplasma pneumoniae: | ||
| mPCR | 54 (10.3) | 2 (3.3) |
| Acute serology IgM | 170 (32.4) | 23 (37.7) |
| Metapneumovirus. mPCR | 37 (7.0) | 0 |
| Adenovirus: | ||
| IFA | 19 (3.6) | 6 (9.8) |
| mPCR | 4 (0.8) | 0 |
| Coronavirus 229E/NL63 and OC43. mPCR | 15 (2.9) | 0 |
| Bordetella pertussis. mPCR | 8 (1.5) | 3 (4.9) |
| Enterovirus. mPCR | 6 (1.6)b | 0 |
| Chlamydophila pneumoniae. mPCR | 1 (0.2) | 0 |
| Bocavirus 1/2/3/4. mPCR | 2 (0.5)b | 0 |
| Legionella pneumophila: | 0 | 1 (1.6) |
| mPCR | 0 | 1 (1.6) |
| UA | 0 | 0 |
IFA indirect immunofluorescence assay, UA Urinary antigen, mPCR multiplex PCR
a UA: n = 515 in CAP group, and n = 50 in control group
b mPCR for Enterovirus and Bocavirus: n = 379 in the CAP group and n = 61 in the control group (commercial diagnostic kit changed during the study to include these two new viruses, from RV12 to RV15 Seeplex® ACE Detection)