Table 3.
General clinical symptoms and frequency of coeliac disease
|
Symptoms1
|
Subjects without coeliac disease (n = 2834), n (%)
|
Coeliac disease (n = 50), n (%)
|
P
value
|
Total (n = 2884), n (%)
|
Frequency of coeliac disease among patients with symptoms (95%CI)
|
P
value
|
|||
| Chronic diarrhea | 258 | 9.1 | 21 | 42.0 | < 0.001 | 279 | 9.7 | 7.53 (4.4-10.6) | < 0.001 |
| Abdominal pain | 1437 | 50.7 | 27 | 54.0 | 0.644 | 1464 | 50.8 | 1.84 (1.2-2.5) | |
| Abdominal distension | 1400 | 49.4 | 29 | 58.0 | 0.228 | 1429 | 49.5 | 2.03 (1.3-2.8) | |
| Constipation | 397 | 14.0 | 5 | 10.0 | 0.417 | 402 | 13.9 | 1.24 (0.2-2.3) | |
| Anorexia | 640 | 22.6 | 20 | 40.0 | 0.004 | 660 | 22.9 | 3.03 (1.7-4.3) | |
| Vomit or/and nausea | 802 | 28.3 | 18 | 36.0 | 0.231 | 820 | 28.4 | 2.20 (1.2-3.2) | |
| Heartburn or/and acid reflux | 740 | 26.1 | 12 | 24.0 | 0.736 | 752 | 26.1 | 1.60 (0.7-2.5) | |
| Belch | 776 | 27.4 | 13 | 26.0 | 0.828 | 789 | 27.4 | 1.65 (0.8-2.5) | |
| Headache or/and dizziness | 677 | 23.9 | 14 | 28.0 | 0.500 | 691 | 24.0 | 2.03 (1.0-3.1) | |
| Anemia | 416 | 14.7 | 20 | 40.0 | < 0.001 | 436 | 15.1 | 4.59 (2.6-6.6) | |
| Fatigue | 536 | 18.9 | 24 | 48.0 | < 0.001 | 560 | 19.4 | 4.29 (2.6-6.0) | |
| Weight loss | 873 | 30.8 | 24 | 48.0 | 0.009 | 897 | 31.1 | 2.68 (1.6-3.7) | |
| Osteopenia or osteoporosis | 329 | 11.6 | 38 | 76.0 | < 0.001 | 367 | 12.7 | 10.35 (7.2-13.5) | |
| Sleep disorder | 771 | 27.2 | 23 | 46.0 | 0.003 | 794 | 27.5 | 2.90 (1.7-4.1) | |
| Anxiety and depression | 808 | 28.5 | 17 | 34.0 | 0.395 | 825 | 28.6 | 2.06 (1.1-3.0) | |
| H. pylori infection | 1627 | 57.4 | 24 | 48.0 | 0.182 | 1651 | 57.2 | 1.45 (0.9-2.0) | |
1
Note that patients had more than one symptom.